來源：Anticancer Res. 2020 Feb;40(2)
題目：Prognostic Value of Age and Distant Metastasis in Differentiated Thyroid Carcinoma Undergoing Salvage Surgery.
年齡和遠處轉移在分化型甲狀腺癌復發後再次手術中的預後價值
AIM:
To investigate the association between survival outcomes and clinicopathological factors, including pathological restaging based on the UICC8, among patients with recurrence differentiated thyroid carcinoma undergoing salvage surgery of local site.
目的：為了研究臨床病理特徵在分化型甲狀腺癌局部復發再次手術後的生存結局。
PATIENTS AND METHODS:
A total of 54 patients who underwent salvage surgery of local site for recurrence differentiated thyroid carcinoma were enrolled. The optimal cutoff ages at salvage surgery for predicting death and cancer-specific death were determined by receiver operating curve analysis. Overall and cancer-specific survivals were determined using log-rank test and Cox's proportional hazards model.
本研究納入54例因局部復發再次手術的分化型甲狀腺癌患者。通過受試者特徵曲線，確定年齡的最佳截取值對再次手術時預測死亡和癌症特異性死亡的價值。
RESULTS:
Univariate analysis showed that age and the presence of distant metastasis at salvage surgery were significantly associated with overall survival (p=0.01 and p<0.05, respectively) and cancer-specific survival (p=0.02 and p=0.01, respectively).
The optimal cutoff age at salvage surgery for predicting the detection of both death (p=0.01) and cancer-specific death (p=0.02) was 65 years. Multivariate analysis showed that age ≥65 years and the presence of distant metastasis were significantly associated with shorter overall survival (p<0.01 and p=0.03, respectively) and shorter cancer-specific survival (p<0.01 and p=0.01, respectively).
結果：單因素分析顯示，年齡和再次手術時有無遠處轉移與總生存率(p=0.01和p<0.05)和腫瘤特異性生存率(p=0.02和p=0.01)呈顯著相關性。
再次手術時預測死亡(p=0.01)和癌症特異性死亡(p=0.02)檢測的最佳年齡截取值是65歲。多因素分析顯示，年齡≥65歲和遠處轉移與總生存期(p<0.0 1和p=0.0 3)和腫瘤特異性生存期(p<0.0 1和p=0.0 1)呈顯著相關性。
CONCLUSION:
Older age and the presence of distant metastasis at salvage surgery of local site were identified as predictors for poor survival outcomes in recurrence differentiated thyroid carcinoma.
結論：高齡和局部再次手術時遠處轉移是復發分化型甲狀腺癌預後不良的預測因素。
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