靶向治疗急性髓细胞性白血病的新方案

的研究,该研究找到了可以同时作用于CKIα和转录激酶CDK7/9的药物小分子,并在临床前模型中可用于治疗AML。Cell, 2017. 168(4): p. 629-643.

3. Papaemmanuil, E., et al., Genomic Classification and Prognosis in Acute Myeloid Leukemia. N Engl J Med, 2016. 374(23): p. 2209-2221.

4. Petzold, G., E.S. Fischer, and N.H. Thoma, Structural basis of lenalidomide-induced CK1alpha degradation by the CRL4(CRBN) ubiquitin ligase. Nature, 2016. 532(7597): p. 127-30.

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6. Ferguson, F.M. and N.S. Gray, Kinase inhibitors: the road ahead. Nat Rev Drug Discov, 2018. 17(5): p. 353-377.

靶向治疗急性髓细胞性白血病的新方案

靶向治疗急性髓细胞性白血病的新方案

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